99.77%+ Purity Purity 99.77% / Avg. mass 11.81 mg Each vial contains 10 mg of highly pure MOTS-c. MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16–amino acid peptide encoded within the mitochondrial genome — one of a small class of mitochondrial-derived peptides (MDPs) that function as systemic signaling molecules rather than structural proteins. MOTS-c has emerged as a key regulator of metabolic homeostasis, with published research demonstrating its involvement in AMPK pathway activation, skeletal muscle glucose uptake, folate-methionine cycle modulation, and adaptive stress response signaling. In preclinical models, MOTS-c administration has been associated with improved insulin sensitivity, enhanced fatty acid oxidation, resistance to diet-induced obesity, and protection against metabolic dysfunction under high-fat and aging conditions. Its unique mitochondrial origin positions it at the interface of mitochondrial communication and nuclear gene regulation — an area of growing interest in metabolic, aging, and exercise physiology research.